Abstract

Possible Implications of Endogenous Cannabinoid Receptors and Transient Receptor Potential Vannaloid-1 (trpv1) Receptors in Alcoholic Neuropathic Induced Pain in Wishtar Rat.

P. Srivastava*, H.N. Yadav, J.K. Gupta

Institute of Pharmaceutical Research, GLA University, Mathura (U.P)

ABSTRACT

Alcoholic neuropathy is caused due to long term consumption of alcohol which leads to degeneration of neurons consequently, leading to neuropathic pain. Trpv1 is a ligand gated channel which gets activated in chronic alcoholism. The present research work . has been design to investigate the involvement of endocannabinoids in the activation of TRPV1 receptor in neuropathic pain during chronic alcoholism in wistar rat. The drugs capsazepine (1mg/kg i.p), a TRPV1 receptor antagonist, tetrahydrolipstatin (12mg/kg i.p), endogenous cannabinoid biosynthesis inhibitor, were given alone as well as in combination, one week before the peak nociception alcoholic rats. Capsaicin (0.1mg/kg i.p), TRPV1receptor agonist were administered for one week after the administration of capsazepine (1mg/kg i.p) in alcoholic rats. Pain were assessed with the help of Eddy’s hot plate, Tail flick method and Tail immersion method. After applied found to be decreasing in alcoholing control group as compared to normal control group. Decrease in pain threshold was obtained in animals which were administered alcohol twice daily.

Keywords: Alcoholic Neuropathic Pain, TRPV1 Receptor Capsaicin, Capsazepine and Tetrahydrolipstatin.