Chemical and pharmacological evaluation of Pyrimidine derivatives of Thiazolidinedion
Neelima Tripathi1, Mrs.Priyanka Patel 1, Mrs. Richa Mishra 1, Mr. Brijesh Mishra1, Dr. A.Balasubramanium2
1. Department of Pharmaceutical Chemistry.Technocrats Tnstitute of TechnologyPharmacy, Anandnagar, Bhopal-462 038 (India)
2. Department of Pharmaceutics.Technocrats Tnstitute of Technology Pharmacy, Anand nagar, Bhopal-462038 (India).
ABSTRACT
The anti-diabetic activity of pyrimidine derivatives of thiazolidinedione were evaluated in alloxan-induced diabetic mice. Pyrimidine derivatives of thiazolidinedione (100 mg/kg body weight), was administered orally to male Swiss albino mice. Alloxan was used to induce diabetes mellitus. The anti-diabetic potential were assessed by determining oral glucose tolerance, fasting blood glucose. Pyrimidine derivatives of thiazolidinedione were administered to normal and experimental diabetic mice for 7 days. After 7 days of treatment with Pyrimidine derivatives of thiazolidinedione the maximum reduction in fasting blood glucose (101.435 ± 2.14) was observed in diabetic mice treated with TZN4(f) (100 mg/kg). The synthesized compounds exhibited dose dependent glucose lowering potential. At a dose of 50mg/kg body weight, no significant reduction in blood glucose could be achieved. Five out of twelve synthesized compounds, viz. TZN 4(b), TZN 4(e), TZN 4(f), TZN 4(k) and TZN 4(l) were observed to be capable of significantly reducing the blood glucose levels at a dose of 100mg/kg body weight.
Keywords: Pyrimidine, Thiazolidinedione, antidiabetic activity.
[Full Text Article]
