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Abstract

5-HT2A Receptor: A Newer Target for Obesity

Jignesh Patel1*, Krupali Mistry2, Anirudh Jain 3

1. Department of Pharmaceutics and Pharmaceutical Technology, SAL Institute of
    Pharmacy, Gujarat, India
2. Drug Inspector, Food and drug department,Gandhinagar, Gujarat, India.
3. Department of Pharmaceutics and Pharmaceutical Technology, SAL Institute of
    Pharmacy, Gujarat, India.

ABSTRACT

Obesity has become major worldwide health problems. Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter that contributes to the regulation of many physiological processes and abnormalities of the serotonergic system have been implicated in the pathogenesis of obesity. 5-HT2A receptor is belongs to Gprotein coupled receptor (GPCR), expressed widely throughout the central nervous system (CNS). Hypothalamic 5-HT2A receptors might have a role in the regulation of feeding and energy homeostasis. 5-HT2A receptor gene expression was increased in association with obesity. 5-HT2A receptor antagonism increases expression of adiponectin and decreases plasminogen activator inhibitor 1 (PAI-1) expression via the 5-HT2A receptor signaling cascade. Recently, development of 5- HT2A receptor antagonists as a novel therapeutic strategy for obesity and associated comorbidities has been the focus of much interest. Here, we describe the role of 5- HT2A receptor in pathogenesis of obesity.

Keywords: Obesity, serotonin, 5-HT2A receptor, sarpogrelate, adiponectin, PAI-1


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