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Abstract

FORMULATION, DEVELOPMENT, EVALUATIO AND CHARACTERIZATION OF BILAYER TABLETS OF AN ANTI-BACTERIAL DRUG

Namrata Tiwari* ,Dr. Amit Pandey, Mrs. DeepaSoni

Department of Pharmaceutics, Shri Rama Krishna College of Pharmacy, Satna M.P.

ABSTRACT

Several pharmaceutical companies are currently developing bi- layer tablets for a variety of reasons like patent extension, therapeutic efficacy, marketing etc. This technology has been used to reduce capital investment. Modified tablet presses have been used to develop bilayer tablets in order to overcome problems associated with tablets like layer separation, insufficient hardness, inaccurate individual layer weight control, cross contamination between the layers, reduce yield etc. When high production output is required a modified tablet press is used. Bilayer tablets are widely used in anti-bacterial therapy to deliver an immediate-release dose for a rapid therapeutic effect, combined with a sustained-release layer to maintain consistent therapeutic levels and reduce dosing frequency. Common antibiotic combinations formulated in this manner include Cefixime with Ofloxacin, Amoxicillin with Lansoprazole, or Ciprofloxacin alone utilizing a bilayer floating drug delivery system.

Keywords: Cefotaxime, Bilayer, Tablet, Sustained release, Novel drug delivery system.


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