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Abstract

ANTI-AMNESIC ACTIVITY OF ACACIA NILOTICA ON SCOPOLAMINEINDUCED AMNESIA IN EXPERIMENTAL ANIMALS

M. V. Gajale*, J. V. Vyas, V. V. Paithankar, A. M. Wankhade

Department of Pharmacology, Vidyabharati College of Pharmacy,Amravati, Maharashtra, India.

ABSTRACT

The present study was undertaken to evaluate the anti-amnesic activity of the ethanolic extract of Acacia nilotica bark against scopolamine-induced amnesia in Swiss albino mice. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, glycosides, saponins, and terpenoids. Memory and learning were assessed using the Elevated Plus Maze, Morris Water Maze, Passive Avoidance Test, and Novel Object Recognition Test. Treatment with the extract significantly improved cognitive performance compared to the scopolamine-induced group (p < 0.0001). The higher dose (75 mg/kg) produced greater improvement and showed effects comparable to the standard drug piracetam. The findings suggest that the ethanolic extract of Acacia nilotica possesses significant anti-amnesic and memory-enhancing activity.

Keywords: Acacia nilotica, Anti-amnesic activity, Scopolamine, Memory, Cognitive function.


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