Login

Journal Front Page

News & Events

  • Call for article for January 2027 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2026 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2026 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 15, Issue 4 (October 2026 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

FORMULATION AND CHARACTERIZATION OF PHOSPHOLIPID COMPLEX OF MEDICINAL PLANT EXTRACT PIPER CUBEBA

Mohammad Zeeshan*, B. K. Dubey, Deepak Basedia

Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.)

ABSTRACT

This study investigates the formulation and characterization of a phospholipid complex of Piper cubeba extract to enhance its bioavailability, stability, and controlled release. The hydroalcoholic extract of Piper cubeba was prepared, and its phytochemical profile revealed the presence of flavonoids, phenols, and tannins, which contribute to its therapeutic properties. The extract was then encapsulated in phospholipid complexes, with formulation F10 being optimized for particle size (260.35 nm) and entrapment efficiency (76.65%). The in-vitro drug release studies indicated a sustained release over 12 hours, with 98.85% of the extract being released. The release pattern followed the Korsmeyer-Peppas model (R² = 0.9719), suggesting a combination of diffusion and erosion-controlled release mechanisms. This phospholipid complex formulation offers a promising approach to improve the pharmacokinetic properties of Piper cubeba and its potential use in therapeutic applications.

Keywords: Piper cubeba, phospholipid complex, bioactive compounds, drug release, entrapment efficiency, sustained release, phytochemical screening, formulation optimization, liposomal delivery.


[Full Text Article]