Abstract

FORMULATION AND EVALUATION OF LOZENGES FOR MOUTH ULCERATION

Sapna Desai, Satyajit Sahoo*, Arjun Chauhan, Vipul Kanojiya, Ishani Vaghasiya

Pioneer Pharmacy College, Vadodara, Gujarat, India – 390019

ABSTRACT

Medicated hard lozenges are a localized drug delivery system containing catechin as the active ingredient, which is released gradually upon dissolution in the oral cavity. Catechin is incorporated for its anti-inflammatory, antioxidant, and wound-healing properties, targeting mouth ulcers either for local action or potential buccal absorption. The oral mucosa serves as a protective barrier, and these lozenges are designed to enhance drug retention at the ulcer site for prolonged therapeutic effect. The medicated hard lozenges were formulated using a fusion method with catechin as the active constituent and excipients such as sucrose, corn syrup, and PEG to provide structural integrity and palatability. Different batches were prepared with varying concentrations of catechin (1–5% w/w). The formulations were evaluated for post-compression parameters (weight variation, hardness, % friability, drug content and disintegration time. Additionally, anti-ulcer activity was assessed by using the Acid neutralizing activity. The formulated catechin-based hard lozenges exhibited desirable phyto-chemical properties, and potent antiulcer activity, making them a promising natural remedy for mouth ulcers.

Keywords: Medicated lozenges, Catechin, anti-inflammatory, mouth ulcers, buccal absorption.