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Abstract

PHYTOCHEMICAL SCREENING AND IN VIVO ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF SPILANTHES OLERACEA

Shaikh Faizur Rahman*, Khushboo Chauhan, Satkar Prasad

RKDF School of Pharmaceutical Sciences, Bhabha University, Bhopal

ABSTRACT

The present study aimed to evaluate the phytochemical composition and anti-ulcerogenic potential of the hydroalcoholic extract of Spilanthes oleracea roots. The extract showed a yield of 11.25% w/w and was found to contain flavonoids, phenols, proteins, carbohydrates, and diterpenes. Quantitative estimation revealed total flavonoid and phenolic contents of 0.854 mg/100 mg and 0.625 mg/100 mg, respectively. The gastroprotective activity was assessed in indomethacin-induced ulcer models in rats by measuring the number of ulcers, ulcer index, gastric pH, and gastric juice volume. Indomethacin caused severe gastric lesions, acidification, and increased gastric volume, while treatment with the extract showed a dose-dependent reduction in ulcer number and index, restoration of gastric pH, and normalization of gastric volume. The extract at 200 mg/kg exhibited significant protection, comparable to standard cimetidine therapy. These findings suggest that the hydroalcoholic extract of Spilanthes oleracea roots possesses notable anti-ulcerogenic activity, likely due to its flavonoid and phenolic constituents, and may serve as a potential natural remedy for gastric ulcers.

Keywords: Spilanthes oleracea, Hydroalcoholic extract, Anti-ulcerogenic, Flavonoids, Phenolic compounds, Gastric ulcer, Indomethacin-induced ulcer, Gastroprotection.


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