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Abstract

FORMULATION AND EVALUATION OF CURCUMIN TOPICAL HYDROGEL FOR SKIN DISEASE

Mohit Dangi, Reena Shende*, Satkar Prasad

RKDF School of Pharmaceutical Sciences, BHABHA Universisty, Madhya Pradesh, India. 462026

ABSTRACT

Curcumin, a natural polyphenolic compound derived from Curcuma longa, possesses well-documented anti-inflammatory, antioxidant, antimicrobial, and wound healing properties. However, its clinical utility is significantly limited by poor water solubility, low chemical stability, and minimal bioavailability. To address these challenges, this study explores the formulation of a curcumin-loaded hydrogel for effective topical delivery. The aim of this research was to develop and evaluate a hydrogel-based delivery system capable of enhancing the solubility, stability, and localized skin delivery of curcumin for potential therapeutic use in inflammatory and infectious skin conditions. A hydrogel formulation containing 0.75, 1.0 and 1.25% carbopol 940 was prepared using Carbopol 940, incorporating curcumin. The formulation was characterized for its physicochemical properties, including pH, viscosity, spreadability, extrudability and drug content. In vitro drug release and skin permeation studies were conducted using Franz diffusion cells. The optimized curcumin hydrogel demonstrated favorable physicochemical properties, sustained drug release over 8 h, and enhanced skin permeation compared to curcumin suspension. The developed curcumin-loaded hydrogel offers a promising platform for topical delivery, overcoming the inherent limitations of curcumin and providing controlled release and targeted action. This formulation may serve as an effective therapeutic strategy for treating skin disorders.

Keywords: Curcumin; Topical hydrogel; Skin disease; Skin permeation.


[Full Text Article]