Abstract

FORMULATION AND CHARACTERIZATION OF SUSTAIN RELEASE TABLETS OF RIVAROXABAN USING NATURAL POLYMERS

Mukesh Chaudhari*, Reena Shende, Satkar Prasad, Sailesh Kumar Ghatuary

RKDF School of Pharmaceutical Sciences, Bhopal (M.P.)

ABSTRACT

Present study aimed to formulate and evaluate sustained release floating tablets of rivaroxaban using natural polymers for improved gastric retention and controlled drug delivery. Pre-compression studies of the powder blend indicated acceptable flow properties suitable for direct compression. Post-compression parameters such as thickness, hardness, friability, weight variation, and drug content were within pharmacopeial limits, ensuring good mechanical strength and uniformity of dosage units. All formulations exhibited buoyancy for more than 12 hours, with formulation F7 showing the shortest floating lag time (32 ± 5 sec). The in-vitro drug release profile of F7 demonstrated sustained release, with 28.85% drug release at 0.5 h and 99.08% at 12 h. Kinetic modeling revealed that drug release followed first-order kinetics (R² = 0.9819) and Korsmeyer–Peppas model (R² = 0.9644), indicating a non-Fickian diffusion mechanism. These findings suggest that natural polymers such as xanthan gum and Carbopol are effective in developing floating sustained release tablets of rivaroxaban, which may enhance therapeutic efficacy and patient compliance by reducing dosing frequency.

Keywords: Rivaroxaban, sustained release tablets, floating drug delivery, natural polymers, xanthan gum, Carbopol, drug release kinetics.