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Abstract

LIPID-BASED CARRIERS IN DRUG DELIVERY: SPOTLIGHT ON SELF-EMULSIFYING SYSTEMS

Diksha Sahu, Reena Shende*, Satkar Prasad, Shailesh Kumar Ghatuwary

RKDF School of Pharmaceutical Sciences, BHABHA University, Bhopal (M.P.)

ABSTRACT

One promising strategy for improving the oral bioavailability of medications that are not very water soluble is the use of self-emulsifying drug delivery systems, or SEDDS. SEDDS increase drug solubilization, absorption, and overall therapeutic efficacy by forming fine oil-in-water emulsions when the gastrointestinal tract is mildly agitated. These systems reduce first-pass metabolism by facilitating lymphatic transport and avoiding the dissolution step, which is frequently a rate-limiting factor in oral drug delivery. For stable emulsification and drug loading, formulation ingredients like oils, surfactants, and co-surfactants are essential. For increased stability, patient compliance, and commercial viability, SEDDS can be further optimized in solid dosage forms (such as tablets and capsules). In conclusion, SEDDS present a flexible and effective delivery system for hydrophobic medications and have a great deal of promise for further pharmaceutical advancement. Therefore, the present review work has been done to give an insight of lipid-based carriers in self-emulsifying systems.

Keywords: SEDDS; Emulsification; Self emulsification; Solubility; Enhancement.


[Full Text Article]