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Abstract

PHYTOCHEMICAL INVESTIGATION AND ANTI-ARTHRITIC ACTIVITY OF FLOWER EXTRACT OF CYMBIDIUM SARAH

Raveesh Kumar*, Sailesh Kumar Ghatuary, Satkar Prasad, Kalpana Prajapati

RKDF School of Pharmaceutical Sciences, Bhopal (M.P.)

ABSTRACT

Medicinal plants are playing an imperative role in the therapy for treating various chronic ailments including arthritis. The present study is aimed to evaluate the in-vivo anti-arthritic activity of ethanolic extract of Cymbidium sarah Jean flower using complete freund’s adjuvant (CFA)-induced model. The latency of the arthritic secondary response ended after a few days and was characterized by joint swelling and nodule events on the 7th day. Administration of Cymbidium Sarah Jean (250 mg/kg) significantly (P < 0.01) protected against joint swelling in paws in rats with induced arthritis compared with the arthritis control group. But a significant reduction was observed from day 11 to day 13 in the Cymbidium sarah treated (200 mg/kg) group. However, the effects of cymbidium sarah at 350 mg/kg were found to be significant (P < 0.001) from the initial stage of the secondary response and were maintained throughout the experiment. They were significant (P < 0.01) 15-19 days after FCA injection compared with the group treated with the reference standard, indomethacin at 10 mg/kg.

Keywords: Cymbidium sarah, Anti-arthritic activity, Extraction, Phytochemical analysis.


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