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Abstract

Formulation and Evaluation of Self-microemulsifying drug delivery system of Curcumin for enhanced solubility and dissolution.

Asit R Sahu1*, Sunil B Bothara2

1C.U.Shah College of Pharmacy & Research, Surendranagar, Gujarat, India.

2Shri Bhagwan College of Pharmacy, Aurangabad, Maharashtra, India

ABSTRACT

Curcumin is a poorly water-soluble drug and its oral bioavailability is very low. A new self- microemulsifying drug delivery system (SMEDDS) has been successfully developed to improve the solubility and oral absorption of curcumin. Suitable compositions of SMEDDS formulation were screened via solubility studies of curcumin and compatibility tests. Pseudoternary phase diagrams were used to evaluate the micro emulsification existence area. Formulation development and screening was done based on results obtained from phase diagram and characteristics of resultant microemulsion. The SMEDDS formulation showed complete release in 10 min as compared with crude drug.

Keywords: Curcumin, Dissolution, SMEDDS, Solubility.


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